Maximize your chance of pregnancy without losing embryos. The endometrial receptivity study is the best diagnostic tool to optimize embryo transfer and is suitable for all patients starting their in vitro fertilization treatment.
The EndomeTRIO consists of one series of 3 different studies that reveal the complete state of health of the endometrium, therefore increasing the possibility of pregnancy. Said studies are:
ERA.
EMMA.
ALICIA.
Did You Know…?
The inside of the uterus is covered by a tissue called endometrium, which forms every month to protect and house the embryo. Currently, 20% of infertility problems are due to endometrial conditions.
The success of an assisted reproduction treatment depends on various factors. Usually, embryos tend to be the main focus, however, the role that the endometrium plays is just as important; if this tissue is not prepared, that is, in its days of receptivity, the pregnancy will not take place.
The EndomeTRIO (Endometrial Testing) Is Recommended For:
Patients who have suffered numerous failures in assisted reproduction treatments.
Women who have not been diagnosed with a condition and have an apparently normal endometrial thickness.
Couples over 35 years old.
ERA – Endometrial Receptivity Test
All women have an “implantation window”,’ which means that the endometrium is more receptive during those days. It is usually between 19-21 days after the last menstruation begins. However, 3 out of 10 women have a displaced implantation window.
An ERA test allows us to know if the patient is in a receptive or non-receptive stage, which allows the specialist to know when is the best time to do the embryo transfer.
Process
An endometrial biopsy involves collecting a sample of the tissue during the patient’s implantation window.
The sample is taken to the laboratory to analyze the 238 genes involved in receptivity.
The state of the endometrium is determined.
The results can be:
Receptive endometrium: The implantation window is present at the time of analysis. The embryo transfer should be done on those optimal days.
Non-receptive endometrium: It means that the implantation window is out of phase and it is not receptive during that period. In this case, a second biopsy – changing the day of the sample – is suggested.
Benefits
Studies have confirmed that an embryo transfer performed on the day the patient is receptive offers better results than a standard day.
Maximize the chance of pregnancy.
Allows the doctor to identify transition phases in 12-hour periods.
EMMA – Endometrial Microbiome Metagenomic Analysis
Among the factors that make the endometrium healthy and ready to receive the embryo is the endometrial microbiome, that is, the bacterial environment of the uterus. The EMMA test determines the abundance of “good” bacteria (lactobacillus) in your endometrium.
When there is an imbalance between healthy bacteria and dysbiotic or pathogenic bacteria, infertility can be caused; this is where the EMMA test comes in handy, as it can determine whether your uterine microbial environment is or is not optimal for embryo implantation.
Process
A sample of the endometrial tissue is obtained through a biopsy. This must be done between days 15 and 25 of the natural cycle.
Next-Generation Sequencing (NGS) technology is used, which provides endometrial microbiome information by analyzing the complete profile of the bacteria present in the tissue.
The state of the uterus is determined.
Benefits
The EMMA test determines if the health status of the uterus is optimal for embryo implantation.
Allows the doctor to give a personalized treatment, as it detects the exact percentage of healthy and infectious bacteria.
EMMA includes the ALICE test, so it can indicate the presence of chronic inflammatory bacteria and other pathogens.
ALICE – Analysis of Infectious Chronic Endometritis
The ALICE test (Analysis of Infectious Chronic Endometritis) is used to diagnose chronic endometritis, which is a uterine infection produced by pathogenic bacteria that causes persistent inflammation of the endometrium, which prevents healthy implantation of the embryo.
It can also detect bacteria associated with sexually transmitted diseases. With this information, our specialists can make a treatment plan with antibiotics and probiotics.
Process
An endometrial sample is collected through a uterine biopsy.
The sample will then be analyzed using Next Generation Sequencing (NGS) technology to provide a complete profile of the bacteria present in the tissue.
If the test is positive, a treatment will be started to balance the endometrial environment.
Benefits
It detects and quantifies the pathogenic bacteria that cause chronic endometritis.
Improves the chances of pregnancy for the patient.
Reduces the risk of implantations failure and recurrent miscarriages.
